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Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

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  • severe pain in your upper stomach spreading to your back, nausea and vomiting;

  • itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

  • high blood sugar (increased thirst, increased urination);

  • penis erection that is painful or lasts 4 hours or longer (if you take Kaletra with erectile dysfunction medication);

  • muscle weakness, tired feeling, joint or muscle pain, feeling short of breath; or

  • severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Kaletra may increase your risk of certain infections or autoimmune disorders by changing the way your immune system works. Symptoms may occur weeks or months after you start treatment with Kaletra. Tell your doctor if you have:

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  • cold sores, sores on your genital or anal area;

  • rapid heart rate, feeling anxious or irritable, weakness or prickly feeling, problems with balance or eye movement;

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  • swelling in your neck or throat (enlarged thyroid), menstrual changes, impotence, loss of interest in sex.

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